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| ![]() ![]() Avascular Necrosis: A Complication of Sickle Cell by Laura Jana, M.D., F.A.A.P. reviewed by Lewis Hsu, M.D., Ph.D. Children with sickle cell disease are susceptible to several types of complications, avascular necrosis among them. This complication occurs in parts of the body where the base-line blood supply is not particularly good, and therefore is more easily obstructed when sickling occurs. The femoral head, located at the top of the thigh bone, or femur, is particularly at risk for this problem. This part of the body (the ball-in-socket hip joint) is more likely than other areas to suffer a loss of blood flow (avascular) as red blood cell sickle and blood flow becomes obstructed. Deprived of blood's important nutrients, including oxygen, tissues fail to survive and begin to break down (necrosis). Besides the hip, avascular necrosis also tends to occur in the shoulders. Unfortunately, scientific studies haven't proven that a child with sickle cell can prevent or lessen the odds of developing avascular necrosis. However, staff members at the Georgia Comprehensive Sickle Cell Center offer these tips based on their own clinical experiences with patients who have sickle cell disease.
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